Although early diagnosis is underutilized in many care settings, children with growth hormone (GH) disorders have developmental delays, obesity, and high costs that are rising globally. This study examines the costs and outcomes of the innovative approaches such as the GH/BMI Screening Interventions on the health and social development of children In LMICs. In the cross-sectional study which was conducted in a multi-center setting, a sample of 1000 children aged between 1 and 10 from multiple countries were enrolled. The collection of the sample, preprocessing, designing of the experiment, and all the statical analyses were done in a systematic manner. The Pre-Development Screening Questionnaire (KPSP) was administered at the beginning of the intervention and periodical intervals and intervals of 3 months to measure mass index, plasma development hormone, and plasma thyroid-stimulating hormone (TSH) levels and developmental milestones attained, in the framework of the 1-year period on the environmental change, muscle activity via exercises, and the guidelines on food to be consumed. The preprocessing of the data included quality control, normalization, and imputation of missing data. Statistical analyses were performed using SPSS v26 and included descriptive statistics, paired t-test, ANOVA, multiple linear regression, and Pearson correlation. The results revealed that there were statistically significant modulations in each of the measured parameters with GH level increased 311% (i.e., from 1.59 ± 0.83 to 6.54 ± 0.87 ng/mL), TSH to be raised up to 5.04 ± 0.32 μIU/ml which could represent higher thyroid function activities, and BMI decreased by about twenty percent (from23.94±0.56to19.23±0.43 kg/m²;all p<:0001). The developmental score improved significantly (R² = 0.65), with BMI decrease and GH increase representing the major most powerful predicting factors at outcome. The cost-benefit analysis modelled significant reductions in health care costs with application to other pediatric populations. Early GH and BMI screening, and application of non-pharmacological measures have strong potential to improve health and save healthcare costs as well as promote social development confirming on separately international pediatric healthcare systems.

Res: Hend R. Tawfik, Ahmed F. Elnokrashy, Samir Y. Marzouk, Mai S. Mabrouk*